منابع مشابه
The steep dose-response curves of anesthesia.
To the Editor:—The critique by Eger et al. on the article by Eckenhoff and Johansson concerns combining the dose–response curves of several ion channels to make them steeper. The slopes of the in vivo studies are steep, whereas those of the in vitro studies are gradual. Both groups anticipate that when several binding sites among ion channels are combined, the dose–response curves may become st...
متن کاملInterpreting steep dose-response curves in early inhibitor discovery.
Many screening hits inhibit enzymes with steep dose-response curves, which are considered pathological. Three models might explain these curves: multisite binding, an inhibitor phase transition, or stoichiometric inhibition caused by a high enzyme to Kd ratio. Experiments with promiscuous aggregators, for which steep curves are common, suggest that these curves owe to stoichiometric inhibition,...
متن کاملCharacteristics of frequency-of-seeing curves for a motion stimulus in glaucoma eyes, glaucoma suspect eyes, and normal eyes
This study compared frequency-of-seeing curves for a line displacement test in glaucoma patients and normals. Probit analysis of the frequency-of-seeing curves provided the motion thresholds and the slopes of the frequency-of-seeing curves, represented by the interquartile range. The thresholds and interquartile ranges were significantly elevated in the glaucoma eyes and suspect eyes, compared ...
متن کاملAmplitude Response Curves of Frequency-Locked Rotations
This letter studies frequency-locked rotations in a phaselocked loop (PLL) circuit as FM demodulator. A rotation represents a desynchronized steady state in the PLL circuit and is regarded as another type of self-excited oscillations with natural rotation frequencies. The rotation frequency can be locked at driving frequencies of modulation signals. This letter shows response curves for harmoni...
متن کاملDerivation of Intensity -Duration-Frequency -Area(IDFA) Curves for Mashhad City
A knowledge of rainfall distribution over a finite area is needed for small bydraulic structures design. Hydrologists have always been concerned about Depth- Area- Duration (DAD) for a specific storm in a watershed. An intense storm occurred on June 6, 1992 which claimed some lives in parts of Mashhad, Khorasan Province, Iran. Data of rainfall depth at 29 raingauge stations around the city and ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1954
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1954.sp005218